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Substance

Phase I - Enzymes (inactivate substrate, activate prodrug)

Phase II - Conjugation Enzymes (make substrate water-soluble)

Phase III - Drug Transport Proteins (affect absorption & excretion)

MAO

Oxydation by Cytochrome P-450 (CYP)

Oxydation by flavin-containing monooxygenase (FMO)

Reduction Enzyme

Glucuronidation by UDP-Glucuronosyltransferase (UGT)

Acetylation

Efflux-Transporter

Solute-Carrier Transporter (SLCT) = Influx & Efflux transporter

MAO-A

1A2

2A6

2B6

2C8

2C9

3A5

2C19

2D6

2E1

3A4

FMO

DPD

VKORC1

1A1

1A3

1A4

1A6

1A9

2B4

2B7

2B10

2B15

2B17

NAT2

BCRP

Pgp (MDR)

OAT1

OAT3

OCT2

MATE1

MATE-2K

OATP1B1

OATP1B3

Abiraterone

INH

Acenocoumarol

SUB

Acetaminophen (Paracetamol)

PRO

SUB

Acyclovir

INH

Adefovir

SUB

Agomelatine

SUB

Alfentanil

SUB

Allopurinol

INH

Alosetron

SUB

Alprazolam

SUB

Alprenolol

SUB

Amiodarone

INH

PRO

INH

Amitriptyline

SUB

PRO

SUB

Amlodipine

INH

SUB

Amodiaquine

SUB

Apixaban

SUB

Aprepitant

IND

INH

SUB

Aripiprazole

SUB

Armodafinil

IND

Artemether

SUB

Artemisinin

IND

SUB

IND

Astemizole

SUB

INH

Asunaprevir

SUB

Atazanavir

INH

SUB

INH

SUB

INH

SUB

INH

Atomoxetine

SUB

Atorvastatin

SUB

INH

SUB

Avanafil

SUB

Beta-Naphthoflavone

IND

Bilirubin

SUB

IND

Bisoprolol

SUB

Boceprevir

INH

SUB

INH

SUB

Bortezomib

SUB

INH

SUB

Bosentan

IND

SUB

IND

SUB

IND

SUB

Broccoli

IND

Bromocriptine

INH

SUB

IND

INH

SUB

Brussel Sprouts

IND

Budesonide

SUB

IND

Bufuralol

SUB

Buprenorphine

SUB

Bupropion

SUB

INH

Buspirone

SUB

Caffeine

SUB

INH

Cannabidiol

INH

SUB

INH

SUB

INH

Carbamazepine

IND

SUB

IND

SUB

IND

PRO

INH

IND

Carisoprodol

SUB

Carvedilol

SUB

PRO

INH

SUB

Cefaclor

SUB

Ceftizoxime

SUB

Celecoxib

SUB

INH

SUB

Celiprolol

IND

SUB

Cerivastatin

SUB

Char-Grilled Meat

IND

Chloramphenicol

INH

SUB

Chloroquine

SUB

INH

SUB

Chlorpheniramine

INH

SUB

Chlorpromazine

INH

SUB

INH

SUB

Chlorzoxazone

SUB

INH

Ciclosporin (Cyclosporine)

INH

SUB

INH

SUB

INH

Cilostazol

INH

SUB

Cimetidine

INH

SUB

Cinacalcet

INH

Ciprofibrate

SUB

Ciprofloxacin

INH

Cisapride

SUB

Citalopram

SUB

INH

SUB

Clarithromycin

INH

SUB

INH

Clemastine

INH

Clobazam

SUB

INH

SUB

Clomipramine

SUB

INH

SUB

PRO

Clonazepam

SUB

Clonidine

SUB

Clopidogrel

PRO

INH

PRO

INH

PRO

SUB

INH

Clotrimazole

INH

IND

Clozapine

SUB

INH

SUB

Cobicistat

INH

SUB

INH

SUB

INH

Cocaine

INH

SUB

Codeine

PRO

SUB

Colchicine

SUB

Conivaptan

INH

SUB

Cortisol

SUB

INH

SUB

Crizotinib

INH

Curcumin

INH

IND

INH

SUB

INH

Cyclobenzaprine

SUB

Cyclophosphamide

PRO

SUB

IND

Dabigatran

SUB

Daclatasvir

SUB

INH

SUB

Danoprevir

INH

SUB

Dapsone

SUB

Darifenacin

SUB

Darunavir

INH

SUB

Dasabuvir

SUB

INH

SUB

INH

SUB

Dasatinib

INH

SUB

Debrisoquine

SUB

Deferasirox

INH

Delavirdine

INH

SUB

INH

SUB

Desipramine

SUB

Desogestrel

SUB

INH

SUB

INH

Desvenlafaxine (active metabolite of venlafaxine)

INH

IND

Dexamethasone

IND

SUB

IND

SUB

Tenofovir

INH

SUB

Dexfenfluramine

SUB

Dextromethorphan

SUB

Diazepam

SUB

Diclofenac

SUB

IND

Dienogest

SUB